Augustus bisgiiler



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AUGUSTUS BISCHLER, OF ZURICH, SW'ITZERLAND, ASSIGNOR TO BASLE CHEMICALWOPJKIS BINDSCHEDLER, OF BASLE, SWITZERLAND.

Wl ETHOXY-ACETPH ENETlDlNa SPECIFICATION forming part of Letters PatentNo. 563,009, dated June 30, 1896. Application filed Augustl0,1895.Serial No. 558,837. (Specimens) T 0 (LN whom it may concern:

Be it known that I, Accusrus BIscHLnR, a subject of the Emperor ofRussia, residing at Zurich, Switzerland, have invented new and usefulImprovements in the Manufacture of Products for Use in Medicine andPharmacy; and I do hereby declare the following to be a full, clear, andexact description of the invention, such as will enable others skilledin the art to which it appertains to make and use the same.

I have found that on heating the alkyloxyfatty acids with primary andsecondary aromatic aniins, new products are formed. All oi theseproducts, which have been subject to clinical tests, hare proved to beof excellent antipyretic, antincuralgic, and other valuable therapeuticeffects.

There are obtained, for instance:

'lfirst, from nrethoxy'acetic acid and anilin the methoXy-ac'etanilid,according to the equation Third, from methoXy-acetic acid and. rne- 1Fifth, from methoXy-acetic acid and para phenetidin theniethorzy-acetparaphonetidid:

Sixth, from cthoxy-acetie acid and paraphenetidin theethoxy-acetparaphen-etidid:

c 11;ocn coon winc s oc n instead of thealkyloXy-fattyacids the chloridsorihe aniids of the alkyloxyiatty acids may be employed in thesereactions.

To ohm-in the new products, one molecule olf an aromatic aminishcatcdwithlittle more than one molecule alkyloxy-acetic acid to 120 lo 150centigrzzdc until no more Water is separated, The product of reaction isthen washed in water and recrystallized from a suitable sol" 1i.

Eco-7'12 ilo One hundred kilos para-plienei;- idin are heated withseventy kilos inethoxyacetic acid during six hours to 130 to 140ccntigradc. The product of reaction is Washed in cold water andrecrystallized from hot 'u'a'i If necessary, the solution is bleachedwith animal charcoal. I

The product, which has Valuable antipyretic and antineuralgicproperties, crystallizes in form of White needles with the melting-pointof 100 to 102 centigrade.

The proper dose of my preparation for an cm,ocmcosnc s ccm mo.

adult is from 0.5 to one gram, taken once during the day, and as much asfive grams" AUGUSTUS niscnmzn.

Witnesses: GEORGE GIFFORD, AMAND BITTER.

